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Sanofi Pasteur inaugurates vaccine production facility to respond to worldwide demand

JUNE 25, 2008 -- VAL DE REUIL, FRANCE -- Sanofi Pasteur, the vaccines division of sanofi-aventis Group, has inaugurated a high-tech vaccine production facility in France to respond to soaring demand worldwide. This new EUR 100 million facility, located in Val de Reuil (Northwestern France), incorporates the latest technology to produce vaccines that meet the highest standards of quality. It is part of EUR 600 million in investments undertaken by Sanofi Pasteur in France between 2005 and 2008.

"Sanofi Pasteur's commitment to global health is exemplified by significant investments in vaccine production infrastructures. These efforts are aimed at meeting a world demand for vaccines expected to double by 2016," says Wayne Pisano, president and CEO of Sanofi Pasteur, who inaugurated the new production unit. "The new facility will provide a high-end production work environment for dedicated people who produce vaccines for the world."

The new highly automated facility can produce vaccines against 20 diseases, reports the company. It is designed to be ready to switch to pandemic influenza vaccine in the event of a human pandemic influenza, and once a pandemic influenza strain is identified by the World Health Organization (WHO).

"Sanofi Pasteur Val de Reuil site is a hub for global health with over two million doses of vaccines shipped worldwide each day. The new facility will further enable Sanofi Pasteur to fulfil its commitment of providing the highest quality vaccines to protect people from infectious diseases wherever they live," adds Pisano.

Construction of the 7,800 m2 building began in 2006. It is projected to be operational by the end of 2008, upon certification by health authorities. The facility is scaled to fill 200 million syringes and vials per year, increasing by two-fold the current capacity at this site.

The new filling lines are part of a EUR 200 million investment project in Val de Reuil that also includes a new building dedicated to vaccine formulation, currently under construction. Formulation, filling, and packaging operations are the last manufacturing steps before vaccines are shipped to customers under cold chain conditions. Formulation and filling are performed in a highly automated aseptic environment that meets the most stringent international Good Manufacturing Practices (GMPs,).

Sanofi Pasteur's Val de Reuil operation is a hub for global health with more than 700 million doses of vaccines per year shipped worldwide. Val de Reuil is also the world's largest production site for seasonal influenza vaccine with 130 million doses produced in 2007, says Sanofi Pasteur.

The Val de Reuil vaccine site was created in 1973 by Institut Pasteur Production. In 1976, Sanofi -- now sanofi-aventis -- invested in Institut Pasteur Production to support its industrial development. Institut Merieux -- now Sanofi Pasteur -- acquired Institut Pasteur Production in 1985.

Sanofi Pasteur has invested more than EUR 1 billion in industrial capacities worldwide during the last five years (2004-2008) to meet the growing global demand for vaccines. Key recent investments include formulation and filling capacities, completion of the world's largest production unit for inactivated polio vaccine, and a new influenza vaccine production facility. In 2008, investments translated into breaking ground on a new production building for pediatric vaccines located in Marcy L'Etoile, near Lyon, France.


About sanofi-aventis
Sanofi-aventis, a leading global pharmaceutical company, discovers, develops, and distributes therapeutic solutions to improve lives. Sanofi Pasteur, the vaccines division of sanofi-aventis Group, provided more than 1.6 billion doses of vaccine in 2007, making it possible to immunize more than 500 million people across the globe. A world leader in the vaccine industry, sanofi pasteur offers the broadest range of vaccines protecting against 20 infectious diseases. The company's heritage, to create vaccines that protect life, dates back more than a century. Sanofi Pasteur is the largest company entirely dedicated to vaccines. Every day, the company invests more than EUR1 million in research and development.

Source: Sanofi Pasteur

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